Serveur d'exploration sur la maladie de Parkinson

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Genetics of Parkinson's disease and parkinsonism

Identifieur interne : 001D61 ( Main/Corpus ); précédent : 001D60; suivant : 001D62

Genetics of Parkinson's disease and parkinsonism

Auteurs : John Hardy ; Huaiban Cai ; Mark R. Cookson ; Katrina Gwinn-Hardy ; Andrew Singleton

Source :

RBID : ISTEX:6FDB66D127E121559A4DA0D9AB3ACBE00279F873

Abstract

Until 10 years ago, conventional wisdom held that Parkinson's disease was not a genetic disorder. Since that time, there have been a plethora of genetic findings, culminating in the cloning of several genes that derive from the loci given the nomenclature PARK1‐PARK12 (OMIM 168600). Recently, these research findings have begun to impact clinical practice, and this impact is likely to increase. The primary purpose of this article is to outline these genetic advances, discuss their importance for current practice in clinical and related settings, and outline briefly how they are influencing research into the causes of and possible future treatments for this prevalent disorder. Ann Neurol 2006;60:389–398

Url:
DOI: 10.1002/ana.21022

Links to Exploration step

ISTEX:6FDB66D127E121559A4DA0D9AB3ACBE00279F873

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<abstract lang="en">Until 10 years ago, conventional wisdom held that Parkinson's disease was not a genetic disorder. Since that time, there have been a plethora of genetic findings, culminating in the cloning of several genes that derive from the loci given the nomenclature PARK1‐PARK12 (OMIM 168600). Recently, these research findings have begun to impact clinical practice, and this impact is likely to increase. The primary purpose of this article is to outline these genetic advances, discuss their importance for current practice in clinical and related settings, and outline briefly how they are influencing research into the causes of and possible future treatments for this prevalent disorder. Ann Neurol 2006;60:389–398</abstract>
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<identifier type="ISSN">0364-5134</identifier>
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<accessCondition type="use and reproduction" contentType="copyright">Copyright © 2006 American Neurological Association</accessCondition>
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